September 19th, 2009 Posted in Uncategorized | 2 Comments »
I have not spoken much about these 2 diseases thus far but they are major problems in this part of South Africa. I am not sure of the exact figures, but about 30-40% of the adult population in Mseleni has HIV. There is great access to ARVs (antiretrovirals) here. When it is determined that ARVs should be initiated the majority are started on a 3 drug regimine called regimen 1a (d4T, 3TC, EFV) with monitoring of their CD4 counts and viral loads. If this regimen is not effective and the patient has been compliant with instructions they will be switched to a different 3 drug regimen called regimen 2. These are the drugs available to the patients and this systematic approach is put in place because of the lack of resources for resistence testing.
Prevention is obviously a very important factor when discussing HIV. Each patient that is tested undergoes pre-test and post-test counseling about the risk factors for disease transmision. I have been working on the maternity ward and about 50 of the 150 total deliveries done here each month are to HIV positive mothers. The mothers are given either ARVs or AZT depending on their CD4 count and the infants are also treated and tested. The mothers are still encouraged to breastfeed for the first 6 months here because the risk of deadly gastroenteritis from improperly fed non-breastfed babies is so high.
10% of those newly diagnosed with HIV will be found to have Tuberculosis within the next year. There are about 75 new cases of TB diagnosed each month at Mseleni hospital or the surrounding clinics. TB is a very interesting disease that can have a very latent, indolent disease course or can be very active and aggressive especially in the face of immunosuppression. Also, TB can affect nearly any structure in the body. In just my few short weeks here I have seen TB meningitis, TB of the spine, a tuberculous knee effusion, and of course lots of pulmonary TB. It is also a difficult disease to treat requiring at least 6 months of a 4 medication regimen. There is developing resistence to the medications and there is plenty of MDR (multidrug resistent) TB in Mseleni.
TB or HIV is a consideration for nearly all of the patients I have seen in the outpatient department since these 2 diseases can affect the body in so many different ways. Nearly every patient gets asked about CLOWNS (Cough, Loss Of Weight, Night Sweats), the hallmark symptoms of TB. On average there are about 1.5 in hospital deaths per day and the majority are HIV or TB related. It is amazing to see the ages at which patients die, many in there 20s and 30s.